GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12143789 | 1 | rs12141651 | chr1:119492703 | WARS2 | chr1:119573841-119683295:- | 0.26 | 4.81 | 1.7E-6 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs6684514 | 1 | rs12142808 | chr1:156230546 | BGLAP | chr1:156182784-156213112:+ | 0.18 | 4.72 | 2.68E-6 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12142808 | chr1:156230546 | C1orf85 | chr1:156259882-156265449:- | -0.12 | -3.47 | 0.000546 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12142808 | chr1:156230546 | CCT3 | chr1:156278752-156308195:- | -0.12 | -3.59 | 0.000352 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs12143789 | 1 | rs12143789 | chr1:119497154 | WARS2 | chr1:119573841-119683295:- | -0.22 | -4.14 | 3.75E-5 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs2275426 | 1 | rs12144263 | chr1:46352446 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.84 | 1.85E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12144263 | chr1:46352446 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.57 | 0.000378 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs12144263 | chr1:46352446 | MUTYH | chr1:45794915-45806142:- | 0.13 | 4.98 | 7.38E-7 | Body mass index |
| BRCA | cis | rs12143789 | 1 | rs12144610 | chr1:119501103 | WARS2 | chr1:119573841-119683295:- | 0.25 | 4.61 | 4.5E-6 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs12145743 | 1 | rs12145743 | chr1:156700651 | C1orf66 | chr1:156698263-156706751:+ | 0.09 | 3.42 | 0.000654 | HDL cholesterol |
| BRCA | cis | rs12145833 | 1 | rs12145833 | chr1:243483754 | SDCCAG8 | chr1:243419320-243663392:+ | 0.23 | 4.88 | 1.24E-6 | Obesity (early onset extreme) |
| BRCA | cis | rs2011013 | 1 | rs12148239 | chr15:84641018 | LOC388152 | chr15:84867600-84898920:- | -0.19 | -5.21 | 2.26E-7 | Sitting height ratio |
| BRCA | cis | rs2404602 | 1 | rs12148786 | chr15:76800362 | SCAPER | chr15:76640529-77197744:- | -0.17 | -5.99 | 2.87E-9 | Blood metabolite levels |
| BRCA | cis | rs12149862 | 1 | rs12149862 | chr16:69497203 | CYB5B | chr16:69458498-69500167:+ | 0.18 | 4.57 | 5.36E-6 | Blood pressure (smoking interaction) |
| BRCA | cis | rs12149862 | 1 | rs12149862 | chr16:69497203 | chr16:69362524-69364498:- | 0.13 | 3.57 | 0.000368 | Blood pressure (smoking interaction) |